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KMID : 1161920190160030084
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Journal of Medicine and Life Science
2019 Volume.16 No. 3 p.84 ~ p.89
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Effect and mechanism of docosahexaenoic acid on the proliferation of dermal papilla cells
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Ko Ji-Yeon
Oh Il-Joong
Kang Jung-Il
Choi Youn-Kyung
Yoon Hoon-Seok
Yoo Eun-Sook
Ko Chang-Ik
Ahn Yong-Seok
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Abstract
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Docosahexaenoic acid (DHA), a principal of mackerel-derived fermented fish oil, increases the proliferation of dermal papilla cells (DPCs) via the upregulation of cell cycle-associated proteins such as cyclin D1 and cdc2 p34, and might promote hair-growth. However, the intracellular mechanisms that underlie the action of DHA in the proliferation of DPCs have not been investigated fully. In this study, we addressed the action mechanisms of DHA to trigger the activation of anagen in DPCs. DHA activated β-catenin signaling by the increased phosphorylation at serine 552 and serine 675 as well as the translocation and accumulation of activated β-catenin into the nucleus. In the other hand, DHA inhibited canonical TGF-β/Smad signaling by the decreased phosphorylation of Smad2/3. Taken together, the results indicate that DHA might stimulate anagen signaling via the activation of Wnt/β-catenin pathway, while the inactivation of canonical TGF-β signaling pathway in DPCs.
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KEYWORD
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Docosahexaenoic acid, Dermal papilla cells, Wnt/β-catenin pathway, TGF-β pathway
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